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Ohio River Cruises 

Ohio River Cruises

9 to 16 Days Ohio River Cruises

American Cruise Lines’ Ohio River Cruises span nine to sixteen days, exploring America’s heartland from Louisville, Pittsburgh, New Orleans, or St. Louis. These immersive journeys highlight historic river towns, Civil War sites, music heritage, and regional culture. Guests sail aboard modern riverboats with spacious staterooms, open decks, and refined dining. Daily included excursions, onboard enrichment, and relaxed pacing create a comfortable, in-depth way to discover the Ohio River’s rich stories and scenic landscapes.

Wi-Fi, Pre-paid Gratuities, Beverages and more!

Cruise Line: American Cruise Lines
Departure: 6/19/2026 to 9/28/2029
Length: 9 to 16 Days
Starting from
$4,110
per person
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Cruise Amenities

Book this trip now with Cruise Specialists and receive the following exclusive amenities!

The American Difference: 
  • The smallest ships with up to 180 guests
  • Full private balconies where indicated
  • Evening entertainment
  • Dedicated historians and experts providing engaging presentations and interactive discussions to the region which you are sailing
  • Included gratuities, port charges and other fees
  • At least one shore excursion every day
  • Signature complimentary cocktail hour every evening
  • Wine and beer service each afternoon and evening
  • Wi-Fi provided by Starlink
  • More than 50 years of experience
  • 100% US company
  • All gourmet meals

Ohio River Cruises

Fares as low as $4,110 and Wi-Fi, Pre-paid Gratuities, Beverages and more!!

Contact Cruise Specialists to book any of these voyages and take advantage of
 Wi-Fi, Pre-paid Gratuities, Beverages and more!!
Fares shown are per person based on double occupancy, in minimum available category, cruise only, in US dollars and may already reflect savings. Offers are valid on select sailings only and applicable to new bookings only. American Cruise Lines, Inc.’s per person fare includes passage, select shore excursions, dining service, snack, complimentary cocktail parties, entertainment, and gratuities aboard the ship. Fares do not include all shore excursions. Ship, itinerary, savings, and schedules are subject to change. Single Occupancy: Single cabins are available on all ships. If one person chooses to occupy a double stateroom, he/she will be charged 150% or 175% of the double occupancy rate depending on the type of stateroom occupied. Ask about the single occupancy rates. Other restrictions apply. We reserve the right to correct errors.
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