American Cruise Lines Mississippi River Cruise

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Mississippi River Cruises

8 to 23-Day Mississippi River Cruises

Cruise the Mighty Mississippi with American Cruise Lines. Travel on the Mississippi aboard elegant new riverboats, where you will be transported back in time to an era of leisurely and romantic travel. From Memphis to New Orleans or St. Paul to St. Louis, you will visit storybook American towns and vibrant, bustling cities combined with the sweeping panoramas and deep blue waters which have inspired musicans, writers and nature enthusiasts. Gain an authentic perspective of the antebellum South and take in the lovely scenery. Experience America's hidden gems while enjoying American Cruise Line's personalized service and luxurious accommodations.

Wi-Fi, Pre-paid Gratuities, Beverages and more!

Cruise Line:	American Cruise Lines
Departure:	9/4/2026 to 12/22/2029
Length:	8 to 23 Days

Starting from

$3,230

per person

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Call us at
(800) 544-2469

Cruise Amenities

Book this trip now with Cruise Specialists and receive the following exclusive amenities!

The American Difference:

The smallest ships with up to 180 guests
Full private balconies where indicated
Evening entertainment
Dedicated historians and experts providing engaging presentations and interactive discussions to the region which you are sailing
Included gratuities, port charges and other fees
At least one shore excursion every day
Signature complimentary cocktail hour every evening
Wine and beer service each afternoon and evening
Wi-Fi provided by Starlink
More than 50 years of experience
100% US company
All gourmet meals

Mississippi River Cruises

Fares as low as $3,230 and Wi-Fi, Pre-paid Gratuities, Beverages and more!!

Many more Mississippi River Cruises to choose from - contact us today!

CRUISE SHIP	DATE	LENGTH	FROM/TO	PRICE
American Melody	9/4/2026	9 Days	Upper Mississippi River Cruise St. Paul, MN to St. Louis, MO	Starting from $7,195 per person	Request a Quote
American Serenade	9/25/2026	16 Days	Grand Heartland Cruise St. Paul, MN to New Orleans, LA	Starting from $14,730 per person	Request a Quote
American Heritage	10/2/2026	12 Days	Mississippi Explorer Cruise Memphis, TN to New Orleans, LA	Starting from $7,275 per person	Request a Quote
American Serenade	10/29/2026	12 Days	Mississippi Explorer Cruise New Orleans, LA to Memphis, TN	Starting from $7,955 per person	Request a Quote
American Heritage	11/25/2026	8 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $3,230 per person	Request a Quote
American Melody	11/27/2026	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,310 per person	Request a Quote
American Melody	12/29/2026	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,775 per person	Request a Quote
American Melody	1/12/2027	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,775 per person	Request a Quote
American Serenade	2/13/2027	8 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $3,855 per person	Request a Quote
American Splendor	2/16/2027	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,295 per person	Request a Quote
American Splendor	3/30/2027	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $5,275 per person	Request a Quote
American Splendor	4/13/2027	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,925 per person	Request a Quote
American Heritage	4/27/2027	8 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $3,990 per person	Request a Quote
American Melody	5/22/2027	23 Days	Complete Mississippi River Cruise New Orleans, LA to St. Paul, MN	Starting from $15,890 per person	Request a Quote
American Splendor	5/25/2027	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,925 per person	Request a Quote
American Serenade	6/11/2027	23 Days	Complete Mississippi River Cruise New Orleans, LA to St. Paul, MN	Starting from $15,890 per person	Request a Quote
American Heritage	6/26/2027	16 Days	Mississippi & Tennessee Rivers Cruise New Orleans, LA to Huntsville, AL	Starting from $8,075 per person	Request a Quote
American Splendor	7/6/2027	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,915 per person	Request a Quote
American Symphony	7/6/2027	14 Days	Mississippi & Ohio Rivers Cruise New Orleans, LA to Louisville, KY	Starting from $8,725 per person	Request a Quote
American Serenade	7/16/2027	9 Days	Upper Mississippi River Cruise St. Paul, MN to St. Louis, MO	Starting from $5,635 per person	Request a Quote
American Serenade	8/27/2027	9 Days	Upper Mississippi River Cruise St. Paul, MN to St. Louis, MO	Starting from $5,635 per person	Request a Quote
American Symphony	9/3/2027	9 Days	Upper Mississippi River Cruise St. Louis, MO to St. Paul, MN	Starting from $5,635 per person	Request a Quote
American Serenade	9/24/2027	16 Days	Grand Heartland Cruise St. Paul, MN to New Orleans, LA	Starting from $12,620 per person	Request a Quote
American Melody	10/8/2027	9 Days	Upper Mississippi River Cruise St. Louis, MO to St. Paul, MN	Starting from $5,995 per person	Request a Quote
American Melody	10/15/2027	16 Days	Grand Heartland Cruise St. Paul, MN to New Orleans, LA	Starting from $12,620 per person	Request a Quote
American Serenade	10/18/2027	12 Days	Mississippi Explorer Cruise Memphis, TN to New Orleans, LA	Starting from $7,770 per person	Request a Quote
American Splendor	10/26/2027	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,925 per person	Request a Quote
American Heritage	10/26/2027	16 Days	Mississippi & Tennessee Rivers Cruise Huntsville, AL to New Orleans, LA	Starting from $9,260 per person	Request a Quote
American Serenade	10/28/2027	8 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $4,880 per person	Request a Quote
American Serenade	11/23/2027	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,275 per person	Request a Quote
American Melody	12/22/2027	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,275 per person	Request a Quote
American Melody	1/12/2028	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $5,275 per person	Request a Quote
American Melody	2/17/2028	8 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $4,255 per person	Request a Quote
American Splendor	2/29/2028	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,610 per person	Request a Quote
American Serenade	3/31/2028	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,995 per person	Request a Quote
American Melody	4/28/2028	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $5,995 per person	Request a Quote
American Heritage	5/12/2028	8 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $3,990 per person	Request a Quote
American Heritage	5/30/2028	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $4,925 per person	Request a Quote
American Melody	6/2/2028	23 Days	Complete Mississippi River Cruise New Orleans, LA to St. Paul, MN	Starting from $15,890 per person	Request a Quote
American Heritage	6/25/2028	16 Days	Mississippi & Tennessee Rivers Cruise New Orleans, LA to Huntsville, AL	Starting from $8,075 per person	Request a Quote
American Splendor	6/27/2028	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,275 per person	Request a Quote
American Melody	6/30/2028	9 Days	Upper Mississippi River Cruise St. Louis, MO to St. Paul, MN	Starting from $5,635 per person	Request a Quote
American Symphony	7/2/2028	16 Days	Mississippi & Ohio Rivers Cruise New Orleans, LA to Louisville, KY	Starting from $9,920 per person	Request a Quote
American Splendor	7/4/2028	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,295 per person	Request a Quote
American Melody	8/25/2028	9 Days	Upper Mississippi River Cruise St. Louis, MO to St. Paul, MN	Starting from $5,275 per person	Request a Quote
American Serenade	8/25/2028	16 Days	Grand Heartland Cruise St. Paul, MN to New Orleans, LA	Starting from $12,620 per person	Request a Quote
American Serenade	9/8/2028	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,275 per person	Request a Quote
American Serenade	9/22/2028	12 Days	Mississippi Explorer Cruise New Orleans, LA to Memphis, TN	Starting from $7,770 per person	Request a Quote
American Symphony	10/10/2028	9 Days	Upper Mississippi River Cruise St. Louis, MO to St. Paul, MN	Starting from $5,995 per person	Request a Quote
American Symphony	10/17/2028	16 Days	Grand Heartland Cruise St. Paul, MN to New Orleans, LA	Starting from $12,620 per person	Request a Quote
American Heritage	10/25/2028	16 Days	Mississippi & Tennessee Rivers Cruise Huntsville, AL to New Orleans, LA	Starting from $9,260 per person	Request a Quote
American Serenade	10/26/2028	12 Days	Mississippi Explorer Cruise New Orleans, LA to Memphis, TN	Starting from $7,770 per person	Request a Quote
American Splendor	10/31/2028	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $4,295 per person	Request a Quote
American Serenade	11/19/2028	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $5,275 per person	Request a Quote
American Symphony	11/26/2028	8 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $4,255 per person	Request a Quote
American Serenade	12/24/2028	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,275 per person	Request a Quote
American Symphony	1/25/2029	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,275 per person	Request a Quote
American Splendor	2/28/2029	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $4,295 per person	Request a Quote
American Melody	3/18/2029	9 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,635 per person	Request a Quote
American Heritage	3/31/2029	7 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $3,720 per person	Request a Quote
American Melody	4/22/2029	9 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $5,995 per person	Request a Quote
American Heritage	5/30/2029	8 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $4,925 per person	Request a Quote
American Melody	6/8/2029	23 Days	Complete Mississippi River Cruise New Orleans, LA to St. Paul, MN	Starting from $15,890 per person	Request a Quote
American Heritage	6/19/2029	7 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $3,720 per person	Request a Quote
American Heritage	6/25/2029	15 Days	Mississippi & Tennessee Rivers Cruise New Orleans, LA to Huntsville, AL	Starting from $8,075 per person	Request a Quote
American Symphony	7/4/2029	15 Days	Mississippi & Ohio Rivers Cruise New Orleans, LA to Louisville, KY	Starting from $9,920 per person	Request a Quote
American Serenade	7/28/2029	8 Days	Upper Mississippi River Cruise St. Louis, MO to St. Paul, MN	Starting from $5,635 per person	Request a Quote
American Serenade	9/25/2029	8 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $5,995 per person	Request a Quote
American Melody	9/29/2029	8 Days	Upper Mississippi River Cruise St. Louis, MO to St. Paul, MN	Starting from $5,635 per person	Request a Quote
American Serenade	10/19/2029	11 Days	Mississippi Explorer Cruise New Orleans, LA to Memphis, TN	Starting from $7,770 per person	Request a Quote
American Heritage	10/25/2029	15 Days	Mississippi & Tennessee Rivers Cruise Huntsville, AL to New Orleans, LA	Starting from $9,260 per person	Request a Quote
American Heritage	11/14/2029	7 Days	Highlights of the Mississippi Cruise Round-trip from New Orleans, LA	Starting from $3,630 per person	Request a Quote
American Serenade	11/22/2029	8 Days	Lower Mississippi River Cruise New Orleans, LA to Memphis, TN	Starting from $5,275 per person	Request a Quote
American Melody	12/22/2029	8 Days	Lower Mississippi River Cruise Memphis, TN to New Orleans, LA	Starting from $5,275 per person	Request a Quote
Looking for more sailing dates for this offer? Contact Us

Contact Cruise Specialists to book any of these voyages and take advantage of
Wi-Fi, Pre-paid Gratuities, Beverages and more!!

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Fares shown are per person based on double occupancy, in minimum available category, cruise only, in US dollars and may already reflect savings. Offers are valid on select sailings only and applicable to new bookings only. American Cruise Lines, Inc.’s per person fare includes passage, select shore excursions, dining service, snack, complimentary cocktail parties, entertainment, and gratuities aboard the ship. Fares do not include all shore excursions. Ship, itinerary, savings, and schedules are subject to change. Single Occupancy: Single cabins are available on all ships. If one person chooses to occupy a double stateroom, he/she will be charged 150% or 175% of the double occupancy rate depending on the type of stateroom occupied. Ask about the single occupancy rates. Other restrictions apply. We reserve the right to correct errors.

We enjoy being part of the Cruise Specialists family. You don’t have to do anything. Luggage is taken care of – we left it on the bus, went to the banquet, and we won’t see it again until the ship.

~ Dave and Marian T., World Cruise Clients